Urine, excreted by the kidneys, is a liquid containing excess water and water-soluble nitrogen-rich metabolic waste including urea, uric acid, and creatinine, which must be cleared from the bloodstream. Urinalysis detects these nitrogenous wastes in .
In , urine travels from the kidneys via the to the bladder and exits the urethra through the penis or vulva during urination. Other excretion urine through the cloaca.
Urine plays an important role in the earth's nitrogen cycle. In balanced , urine fertilizes the soil and thus helps to grow. Therefore, urine can be used as a fertilizer. Some animals mark their territories with urine.[MacDonald, David W. "Patterns of scent marking with urine and faeces amongst carnivore communities." Symposia of the Zoological Society of London. Vol. 45. No. 107. 1980.] Historically, aged or fermented urine (known as lant) was also used in gunpowder production, household cleaning, leather tanning, and textile dyeing.
Human urine and human feces, called human waste or human excreta, are managed via sanitation systems. Livestock urine and feces also require proper management if the livestock population density is high.
Physiology
Most animals have
for elimination of soluble toxic wastes. In humans, soluble wastes are excreted primarily by the
urinary system and, to a lesser extent in terms of
urea, removed by
perspiration.
In placental mammals, the urinary system consists of the
,
,
urinary bladder, and
urethra. The system produces urine by a process of
filtration, reabsorption, and
Renal physiology. The kidneys extract the soluble wastes from the bloodstream, as well as excess water, sugars, and a variety of other compounds. The resulting urine contains high concentrations of urea and other substances, including toxins. Urine flows from the kidneys through the ureter, bladder, and finally the urethra before passing through the
urinary meatus.
Duration
Research looking at the duration of urination in a range of
mammal species found that nine larger species urinated for 21 ± 13 seconds irrespective of body size.
Smaller species, including
and
, cannot produce steady streams of urine and instead urinate with a series of drops.
Characteristics
Quantity
Average urine production in adult humans is around of urine per person per day with a normal range of per person per day, produced in around 6 to 8 urinations per day depending on state of hydration, activity level, environmental factors, weight, and the individual's health.
[ Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License .] Producing too much or too little urine needs medical attention.
Polyuria is a condition of excessive production of urine (> 2.5 L/day),
oliguria when < 400 mL are produced, and
anuria being < 100 mL per day.
Constituents
About 91–96% of urine consists of water.
The remainder can be broadly characterized into inorganic salts, urea, organic compounds, and organic ammonium salts.
Urine also contains proteins, hormones, and a wide range of
,
varying by what is introduced into the body.
The total solids in urine are on average per day per person. Urea is the largest constituent of the solids, constituting more than 50% of the total. The daily volume and composition of urine varies per person based on the amount of physical exertion, environmental conditions, as well as water, salt, and protein intakes. In healthy persons, urine contains very little protein and an Proteinuria is suggestive of illness, as with sugar. Organic matter, in healthy persons, also is reported to at most 1.7 times more matter than minerals. However, any more than that is suggestive of illness.
+ Typical design values for the concentrations of constituents in fresh urine, based on data in Sweden and Switzerland |
|
6.2 |
8,830 mg/L |
460 mg/L |
0.06 mg/L |
6,000 mg/L |
800–2,000 mg/L |
2,740 mg/L |
1,500 mg/L |
3,450 mg/L |
120 mg/L |
4,970 mg/L |
230 mg/L |
However, it is important to note that lesser amounts and concentrations of other compounds and
are often present in urination of humans.
Color
Urine varies in appearance, depending principally upon a body's level of
tissue hydration, interactions with drugs, compounds and
or
found in food, or diseases.
Normally, urine is a transparent solution ranging from colorless to amber, but is usually a pale yellow.
Usually urination color comes primarily from the presence of
urobilin.
Urobilin is a final waste product resulting from the breakdown of
heme from
hemoglobin during the destruction of aging blood cells.
Colorless urine indicates over-hydration. Colorless urine in drug tests can suggest an attempt to avoid detection of illicit drugs in the bloodstream through over-hydration.
-
Bloody urine is termed hematuria, a symptom of a wide variety of medical conditions.
-
Reddish or brown urine may be caused by porphyria (not to be confused with the harmless,
temporary pink or reddish tint caused by beeturia).
-
Pinkish urine can result from the consumption of (beeturia)
-
Dark yellow urine is often indicative of dehydration.
-
Orange urine due to certain medications such as rifampin and phenazopyridine
-
Dark orange to brown urine can be a symptom of jaundice, rhabdomyolysis, or Gilbert's syndrome.
-
Greenish urine can result from the consumption of asparagus or foods, beverages with green pigments, or from a urinary tract infection.
-
Blue urine can be caused by the ingestion of methylene blue (e.g., in medications) or foods or beverages with blue dyes.
-
Blue urine stains can be caused by blue diaper syndrome.
-
Purple urine may be due to purple urine bag syndrome.
-
Black or dark-colored urine is referred to as melanuria and may be caused by a melanoma or non-melanin acute intermittent porphyria.
Odor
Sometime after leaving the body, urine may acquire a strong "fish-like" odor because of contamination with bacteria that break down urea into
ammonia. This odor is not present in fresh urine of healthy individuals; its presence may be a sign of a urinary tract infection.
The odor of normal human urine can reflect what has been consumed or specific diseases. For example, an individual with diabetes mellitus may present a sweetened urine odor. This can be due to kidney diseases as well, such as kidney stones. Additionally, the presence of in urine (diagnosed as maple syrup urine disease) can cause it to smell of maple syrup.
Eating asparagus can cause a strong odor reminiscent of the vegetable caused by the body's breakdown of asparagusic acid. Likewise consumption of saffron, ethanol, coffee, tuna fish, and onion can result in telltale scents. Particularly spicy foods can have a similar effect, as their compounds pass through the kidneys without being fully broken down before exiting the body.[ Foods that Affect the Odor of Urine. livestrong.com. December 27, 2010.]
pH
The pH normally is within the range of 5.5 to 7 with an average of 6.2.
In persons with
hyperuricosuria, acidic urine can contribute to the formation of stones of
uric acid in the kidneys, ureters, or bladder.
Urine pH can be monitored by a physician or at home.
[
]
A diet which is high in protein from meat and dairy, as well as alcohol consumption can reduce urine pH, whilst potassium and organic acids, such as from diets high in fruit and vegetables, can increase the pH and make it more alkaline.
Cranberries, popularly thought to decrease the pH of urine, have actually been shown not to acidify urine. Drugs that can decrease urine pH include ammonium chloride, chlorothiazide diuretics, and methenamine mandelate.[ Urine pH: MedlinePlus Medical Encyclopedia . Nlm.nih.gov (2011-03-28). Retrieved on 2011-04-27.][ Discovery Health "Urine PH – Medical Dictionary" . Healthguide.howstuffworks.com (2007-05-16). Retrieved on 2011-04-27.]
Density
Human urine has a specific gravity of 1.003–1.035.
Bacteria and pathogens
Urine is not
Asepsis, not even in the bladder,
contrary to longstanding popular belief. This opened a new area of study: the urinary
microbiome. In the urethra,
Epithelium lining the urethra are colonized by facultatively anaerobic Gram-negative rod and cocci bacteria.
One study conducted in Nigeria isolated a total of 77 distinct bacterial strains from 100 healthy children (ages 5–11) as well as 39 strains from 33 cow urine samples, a considerable amount being pathogens.
Pathogens identified and their percentages were:
The study also states:
Examination for medical purposes
Many physicians in ancient history resorted to the inspection and examination of the urine of their patients. Hermogenes wrote about the color and other attributes of urine as indicators of certain diseases.
Ibn Habib of
Andalusia ( 862 AD) mentions numerous reports of urine examination throughout the
Umayyad empire.
[Ibn Habib, Abdul Malik d.862CE/283AH "Kitaab Tib Al'Arab" (The Book of Arabian Medicine), Published by Dar Ibn Hazm, Beirut, Lebanon 2007(Arabic)] Diabetes mellitus got its name because the urine is
polyuria and
sweetness.
The name
uroscopy refers to any visual examination of the urine,
including
microscopy, although it often refers to the aforementioned prescientific or Proto-scientific forms of urine examination. Clinical urine tests today duly note the color, turbidity, and odor of urine but also include
urinalysis, which chemically analyzes the urine and quantifies its constituents. A culture of the urine is performed when a urinary tract infection is suspected, as
bacteriuria without symptoms does not require treatment.
[Köves, B; Cai, T; Veeratterapillay, R; Pickard, R; Seisen, T; Lam, TB; Yuan, CY; Bruyere, F; Wagenlehner, F; Bartoletti, R; Geerlings, SE; Pilatz, A; Pradere, B; Hofmann, F; Bonkat, G; Wullt, B (25 July 2017). "Benefits and Harms of Treatment of Asymptomatic Bacteriuria: A Systematic Review and Meta-analysis by the European Association of Urology Urological Infection Guidelines Panel". European Urology. 72 (6): 865–868. PMID 28754533.] A microscopic examination of the urine may be helpful to identify organic or inorganic substrates and help in the diagnosis.
The color and volume of urine can be reliable indicators of hydration level. Clear and copious urine is generally a sign of adequate hydration. Dark urine is a sign of dehydration. The exception occurs when diuretics are consumed, in which case urine can be clear and copious and the person still be dehydrated.
Uses
Source of medications
Urine contains proteins and other substances that are useful for medical therapy and are ingredients in many prescription drugs (e.g., Ureacin,
Urecholine, Urowave). Urine from
menopause women is rich in
that can yield follicle stimulating hormone and luteinizing hormone for fertility therapy.
One such commercial product is
Pergonal.
Urine from pregnant women contains enough human chorionic gonadotropins for commercial extraction and purification to produce hCG medication. Pregnant mare urine is the source of , namely Premarin. Urine also contains Antibody, which can be used in diagnostic antibody tests for a range of , including HIV-1.[ Urine Antibody Tests: New Insights into the Dynamics of HIV-1 Infection – Urnovitz et al. 45 (9): 1602 – Clinical Chemistry . Clinchem.org. Retrieved on 2011-04-27.]
Urine can also be used to produce urokinase, which is used clinically as a Thrombolysis agent.
Fertilizer
Cleaning
Given that urea in urine breaks down into ammonia, urine has been used for cleaning. In pre-industrial times, urine was used – in the form of
lant or aged urine – as a cleaning fluid.
[Sueton, Vespasian 23 English , Latin . Cf. Dio Cassius, Roman History, Book 65, chapter 14,5 English , Greek/French (66, 14) ] Urine was also used for whitening teeth in Ancient Rome.
Gunpowder
Urine was used before the development of a chemical industry in the manufacture of
gunpowder. Urine, a nitrogen source, was used to moisten straw or other organic material, which was kept moist and allowed to rot for several months to over a year. The resulting salts were washed from the heap with water, which was evaporated to allow collection of crude saltpeter crystals, that were usually refined before being used in making gunpowder.
Survival uses
Urophagia is the consumption of urine. Urine was consumed in several ancient cultures for various health, healing, and cosmetic purposes. People have been known to drink urine in extreme cases of water scarcity.
The US Army Field Manual advises drinking urine for survival. The manual explains that drinking urine tends to worsen rather than relieve dehydration due to the salts in it, and that urine should not be consumed in a survival situation, even when there is no other fluid available. In hot weather survival situations, where other sources of water are not available, soaking cloth (a shirt for example) in urine and putting it on the head can help cool the body.[ Water Procurement , US Army Field Manual]
During World War I, Germans experimented with numerous poisonous gases as weapons. After the first German chlorine gas attacks, Allied troops were supplied with masks of cotton pads that had been soaked in urine. It was believed that the ammonia in the pad neutralized the chlorine. These pads were held over the face until the soldiers could escape from the poisonous fumes.
Urban legend states that urine works well against jellyfish stings.[Castillo, M. (2017, June 20). Don't Pee On A Jellyfish Sting — It Won'
]
/ref> This scenario has appeared many times in popular culture including in the Friends episode "The One With the Jellyfish", an early episode of Survivor, as well as the films The Real Cancun (2003), The Heartbreak Kid (2007) and The Paperboy (2012). However, at best it is ineffective, and in some cases this treatment may make the injury worse.[ Fact or Fiction?: Urinating on a Jellyfish Sting is an Effective Treatment . Scientific American. 4 January 2007. Retrieved on 2011-04-27.][ Jellyfish Sting Treatment – How to Treat a Jellyfish Sting . Firstaid.about.com. 22 August 2010. Retrieved on 2011-04-27.]
Textiles
Urine has often been used as a mordant to help prepare textiles, especially wool, for dyeing. In the Scottish Highlands and Hebrides, the process of "waulking" (fulling) woven wool is preceded by soaking in urine, preferably infantile.[Mentioned by an interviewee in Lomax the Songhunter, a 2004 documentary film.]
Olfactory communication
Urine plays a role in olfactory communication, since it contains that act as Pheromone. The urine of predator species often contains that serve as a animal repellent against their prey species.[Swihart, Robert K., Joseph J. Pignatello, and Mary Jane I. Mattina. "Aversive responses of white-tailed deer, Odocoileus virginianus, to predator urines." Journal of chemical ecology 17.4 (1991): 767-777.]
History
The fermentation of urine by bacteria produces a Ammonia solution; hence fermented urine was used in Classical Antiquity to wash cloth and clothing, to remove hair from hides in preparation for tanning, to serve as a mordant in dying cloth, and to remove rust from iron.[See:
]
-
Forbes, R.J., Studies in Ancient Technology, vol. 5, 2nd ed. (Leiden, Netherlands: E.J. Brill, 1966), pp. 19 , 48 , and 65 .
-
Moeller, Walter O., The Wool Trade of Ancient Pompeii (Leiden, Netherlands: E.J. Brill, 1976), p. 20.
-
Faber, G.A. (pseudonym of: Goldschmidt, Günther) (May 1938) "Dyeing and tanning in classical antiquity," Ciba Review, 9 : 277–312. Available at: Elizabethan Costume
-
Smith, William, A Dictionary of Greek and Roman Antiquities (London, England: John Murray, 1875), article: "Fullo" (i.e., fullers or launderers), pp. 551–553.
-
Rousset, Henri (31 March 1917) "The laundries of the Ancients," Scientific American Supplement, 83 (2152) : 197.
-
Bond, Sarah E., Trade and Taboo: Disreputable Professions in the Roman Mediterranean (Ann Arbor, Michigan: University of Michigan Press, 2016), p. 112.
-
Binz, Arthur (1936) "Altes und Neues über die technische Verwendung des Harnes" (Ancient and modern information about the technological use of urine), Zeitschrift für Angewandte Chemie, 49 (23) : 355–360. in
-
Witty, Michael (December 2016) "Ancient Roman urine chemistry," Acta Archaeologica, 87 (1) : 179–191. Witty speculates that the Romans obtained ammonia in concentrated form by adding wood ash (impure potassium carbonate) to urine that had been fermented for several hours. Struvite (magnesium ammonium phosphate) is thereby precipitated, and the yield of struvite can be increased by then treating the solution with bittern, a magnesium-rich solution that is a byproduct of making salt from sea water. Roasting struvite releases ammonia vapors.
Ancient Rome used fermented human urine (in the form of lant) to cleanse grease stains from clothing. The emperor Nero instituted a tax () on the urine industry, continued by his successor, Vespasian. The Latin saying Pecunia non olet ('money does not smell') is attributed to Vespasian – said to have been his reply to a complaint from his Titus about the unpleasant nature of the tax. Vespasian's name is still attached to public urinals in France (vespasiennes), Italy (vespasiani), and Romania (vespasiene).
Alchemy spent much time trying to extract gold from urine, which led to discoveries such as white phosphorus by German alchemist Hennig Brand when distilling fermented urine in 1669. In 1773 the French chemist Hilaire Rouelle discovered the organic compound urea by boiling urine dry.
Language
The English word urine (, ) comes from the Latin urina ( -ae, f.), which is cognate with ancient words in various Indo-European languages that concern water, liquid, diving, rain, and urination (for example Sanskrit meaning 'it rains' or meaning 'water' and Greek meaning 'to urinate'). The Onomatopoeia term piss predates the word urine, but is now considered vulgar.[
]
Urinate was at first used mostly in medical contexts. Piss is also used in such colloquialisms as to piss off, piss poor, and the slang expression pissing down to mean heavy rain. and baby talk (such as wee, pee, number one and many others) have long existed.
Lant is a word for aged urine, originating from the Old English word hland referring to urine in general.
See also
Notes
External links