Sulforaphane

 ( Experimental Cancer Drugs ) 

Sulforaphane (sometimes sulphoraphane in British English) is a phytochemical within the isothiocyanate group of organosulfur compounds. Although sulforaphane research on cancer has been ongoing for many years, there is no good clinical evidence to indicate consuming sulforaphane-rich vegetables or dietary supplements provides any effect.

---

Biosynthesis It is produced when the enzyme myrosinase transforms glucoraphanin, a glucosinolate, into sulforaphane upon damage to the plant (such as from chewing or chopping during food preparation), which allows the two compounds to mix and react.

Sulforaphane is present in cruciferous vegetables, such as broccoli, , and cabbage. Sulforaphane has two possible due to the presence of a stereogenic sulfur atom.

---

Occurrence and isolation Sulforaphane occurs in broccoli sprouts, which, among cruciferous vegetables, have the highest concentration of glucoraphanin, the precursor to sulforaphane. It is also found in cabbage, cauliflower, , bok choy, kale, collards, Mustard plant, and watercress.

Under conditions where broccoli is cooked, sulforaphane converts to the thiourea () as well as some 1,2,4-trithiolane.

---

Research

Although substantial animal research on the possible anti-cancer effects of sulforaphane has been reported, there is no substantial clinical research to indicate consuming foods rich in sulforaphane provides any benefit against cancer.

---

See also

• Raphanin

Categories: Experimental Cancer Drugs, Isothiocyanates, Sulfoxides, Histone Deacetylase Inhibitors, 1,4-butanediyl Compounds

Post Comment