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A diastase (; from διάστασις, "separation") is any one of a group of that the breakdown of into . For example, the diastase α-amylase degrades starch to a mixture of the disaccharide maltose; the trisaccharide maltotriose, which contains three α (1-4)-linked glucose residues; and oligosaccharides, known as dextrins, that contain the α (1-6)-linked glucose branches.

Diastase was the first enzyme discovered.See:

Persoz found diastase in the seeds of barley, oats, and wheat, as well as in potatoes (Payen & Persoz (1833), page 76). The name "diastase" comes from the Greek word διάστασις ( diastasis) (a parting, a separation), because when beer is heated, the enzyme causes the starch in the barley seed to transform quickly into soluble sugars and hence the husk to separate from the rest of the seed.Payen & Persoz (1833), pages 75-76. Today, "diastase" refers to any α-, β-, or γ- (all of which are ) that can break down .
(2025). 9780199912100, Oxford University Press. .

The commonly used suffix for naming enzymes was derived from the name diastase.The naming of enzymes using the suffix "-ase" has been traced to French scientist Émile Duclaux (1840-1904), who intended to honor the discoverers of diastase by introducing the practice in his book Traité de Microbiologie, vol. 2 (Paris, France: Masson and Co., 1899), Chapter 1, especially page 9.

When used as a pharmaceutical drug, diastase has the .

Amylases can also be extracted from other sources including plants, saliva and milk.


Clinical significance
Urine diastase is useful in diagnosing uncertain abdominal cases (especially when is suspected), stones in the common bile duct (choledocholithiasis), and in ruling out post-operative injury to the pancreas; provided that the diastase level is correlated with clinical features of the patient.

Diastase is also used in conjunction with periodic acid–Schiff stain in histology. For example, glycogen is darkly stained by PAS but can be dissolved by diastase. Fungi, on the other hand, stain darkly with PAS even after treatment by diastase.


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