Cefotetan is an injectable antibiotic of the cephamycin type for prophylaxis and treatment of bacterial infections. It is often grouped together with second-generation and has a similar antibacterial spectrum, but with additional anti-anaerobe coverage.
Cefotetan was developed by Astellas Pharma. It is marketed outside Japan by AstraZeneca with the brand names Apatef and Cefotan.
Adverse effects
The chemical structure of cefotetan, like that of several other cephalosporins, contains an
N-methylthiotetrazole (NMTT or 1-MTT)
side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to
enzyme inhibitor of the
enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by
disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.
Spectrum of bacterial susceptibility
Cefotetan has a broad spectrum of activity and has been used to treat bacterial infections of the bone, skin, urinary tract, and lower respiratory tract. Notable species include
Bacteroides, Streptococcus, and
Escherichia. The following represents MIC susceptibility data for a few medically significant bacteria.
-
Escherichia coli: 0.06 μg/mL
-
Bacteroides fragilis: ≤0.06 μg/mL - 512 μg/mL
-
Clostridium perfringens: 1 μg/mL - 4 μg/mL
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