Product Code Database
Butriptyline, sold under the brand name Evadyne among others, is a tricyclic antidepressant (TCA) that has been used in the United Kingdom and several other countries for the treatment of depression but appears to no longer be marketed.Swiss Pharmaceutical Society (2026). 9783887630751, Medpharm Scientific Publishers. . ISBN 9783887630751 (2007). 9783527310586, Wiley. ISBN 9783527310586 Along with trimipramine, iprindole, and amoxapine, it has been described as an "atypical" or "second-generation" TCA due to its relatively late introduction and atypical pharmacology. (2009). 9788131211588, Elsevier India. ISBN 9788131211588 (2026). 9788181470096, Elsevier India. ISBN 9788181470096 It was very little-used compared to other TCAs, with the number of prescriptions dispensed only in the thousands.
Butriptyline has potent antihistamine effects, resulting in sedation and somnolence. It also has potent anticholinergic effects, (1990). 9783718650279, CRC Press. ISBN 9783718650279 resulting in side effects like dry mouth, constipation, urinary retention, blurred vision, and cognitive/memory impairment. The drug has relatively weak effects as an alpha-1 blocker and has no effects as a norepinephrine reuptake inhibitor, so is associated with little to no antiadrenergic and adrenergic side effects.
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| Values are Ki (nM), unless otherwise noted. The smaller the value, the more strongly the drug binds to the site. | |||
In vitro, butriptyline is a strong antihistamine and anticholinergic, moderate 5-HT2 and α1-adrenergic receptor antagonist, and very weak or negligible monoamine reuptake inhibitor. These actions appear to confer a profile similar to that of iprindole and trimipramine with serotonin-blocking effects as the apparent predominant mediator of mood-lifting efficacy.
However, in small , using similar doses, butriptyline was found to be similarly effective to amitriptyline and imipramine as an antidepressant, despite the fact that both of these TCAs are far stronger as both 5-HT2 antagonists and serotonin–norepinephrine reuptake inhibitors. (2013). 9781483191935, Elsevier. ISBN 9781483191935 As a result, it may be that butriptyline has a different mechanism of action, or perhaps functions as a prodrug in the body to a metabolite with different pharmacodynamics.
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