Aescin

 ( Saponins ) 

Aescin or escin is a mixture of with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum (the horse chestnut). Aescin is the main active component in horse chestnut, and is responsible for most of its medicinal properties. The main active compound of aescin is β-aescin, although the mixture also contains various other components including α-aescin, protoescigenin, barringtogenol, cryptoescin and .

Evidence suggests that aescin, especially pure β-aescin, is a safe and effective treatment for short-term treatment of chronic venous insufficiency;

however, more high quality randomized controlled trials are required to confirm the effectiveness. Horse chestnut extract may be as effective and well tolerated as the use of compression stockings.

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Mechanism of action

Aescin appears to produce effects through a wide range of mechanisms. It induces endothelial NOS by making more permeable to calcium ions, and also induces release of dinoprost. Other possible mechanisms include serotonin antagonism and histamine antagonism and reduced catabolism of tissue mucopolysaccharides.

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External links

• Information on horse chestnut extract from Memorial Sloan-Kettering Cancer Center
• - alpha-Aescin

Categories: Saponins, Triterpene Glycosides, Acetate Esters

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