Oostakker (; formerly spelled Oostacker) is a sub-municipality of the city of Ghent located in the East Flanders, Flemish Region, Belgium. It was a separate municipality until 1977. In 1872, Sint-Amandsberg was detached from Oostakker. In 1900, 1920 and 1927, parts of the original municipality were already annexed to Ghent. On 1 January 1977, the municipality of Oostakker was merged into Ghent.
The hamlet is mainly known for the Shrine of Oostakker, a Roman Catholic shrine of the Virgin Mary. Residents of Oostakker are called Oostakkezen.
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