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A kinin is any of various structurally related peptides, such as bradykinin and kallidin. They are members of the autacoid family. Kinins are peptides that are cleaved from kininogens by the process of Kallikrein. Kallikreins activate kinins when stimulated.
It is a component of the kinin-kallikrein system.
Their precursors are . Online Medical Dictionary Kininogens contain a 9-11 amino acid bradykinin sequence.
In botany, the known as were first called kinins; the name was changed to avoid confusion. (2025). 9780444531803 ISBN 9780444531803
Kinins act on Axon to block nerve impulses, which leads to distal muscle relaxation. They are also potent nerve stimulators which are mostly responsible for the pain sensation (and sometimes Itch). Kinins increase vascular permeability by acting on vascular Endothelium cells to cause cell contraction. Concomitantly, they induce local expression of adhesive molecules. Together they increase white blood cell adhesion and extravasation. Kinins are rapidly inactivated by the Protease generated locally during the aforementioned processes.Textbook Immunology: a short course, 5th ed, Coico R, Sunshine G, Benjamini E.Wiley-Liss
They act locally to induce vasodilation and contraction of smooth muscle. Kinins function as mediators for Inflammation responses by triggering the immune system. They are also able to regulate cardiovascular and Renal function (kidney) function by mediating the effects of ACE inhibitor. (2011). 9780470650714 ISBN 9780470650714 Reduced kinin activity can result in Hypertension, Hypernatremia, and the narrowing of blood vessels.
Aspirin inhibits the activation of kallenogen by interfering with the formation of the kallikrein enzyme, which is essential in the process of activation.
B1 and B2 receptors are essentially related as Homologous gene. Both have the same cellular signaling pathways, although their patterns are different in intensity and duration; the B1 signaling pathway lasts longer than the B2 signaling pathway.
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