Product Code Database
Ellipticine is a tetracyclic alkaloid first extracted from the tree species Ochrosia elliptica and Rauvolfia sandwicensis
It was first isolated from Ochrosia elliptica Labill., a flowering tree native to Australia and New Caledonia which gives the alkaloid its name, in 1959, and synthesised by Robert Burns Woodward later the same year.
and lies parallel to the base pairs,
increasing the DNA supercoil of the DNA.
Intercalated ellipticine binds directly to topoisomerase II, an enzyme involved in DNA replication,
inhibiting the enzyme and resulting in powerful antitumour activity. In clinical trials, ellipticine derivatives have been observed to induce remission of tumour growth, but are not used for medical purposes due to their high toxicity; side effects include nausea and vomiting, hypertension, cramp, pronounced fatigue, mouth dryness, and mycosis of the tongue and oesophagus.
(1980). 9783642814907 ISBN 9783642814907
Further DNA damage results from the formation of covalent following enzymatic activation of ellipticine by with P450 and , meaning that ellipticine is classified as a prodrug.
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