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Atul Janardhan Butte (August 26, 1969 – June 13, 2025) was an American biomedical informatician, pediatrician and biotechnology businessman. He was the Priscilla Chan and Mark Zuckerberg Distinguished Professor at the University of California, San Francisco. In 2015, Butte became the inaugural director of UCSF's Bakar Computational Health Sciences Institute.
Butte completed a residency in pediatrics and a fellowship in pediatric endocrinology, both at Children's Hospital Boston. In 2004, he completed a Ph.D. from the Harvard–MIT Division of Health Sciences and Technology, supervised by Dr. Isaac Kohane.
Butte moved to California and became an assistant professor at Stanford University in 2005. He later became the Chief of the Division of Systems Medicine at Stanford University School of Medicine and Lucile Packard Children's Hospital where he held the position of an associate professor of pediatrics and (by courtesy) computer science and immunology & rheumatology. He moved to the University of California, San Francisco in 2015.
In April 2012, Butte delivered a TEDMED talk describing his lab's development of techniques using massive amount of publicly available biomedical research data to make new discoveries without running a wet-lab and actually outsourcing experiments using assaydepot.com.
Butte had an h-index of over 110 and was recognized by Publons as a highly cited researcher with over 70,000 citations. He founded two biotechnology companies (Personalis and NuMedii) and wrote one of the first books on microarray analysis, Microarrays for an Integrative Genomics.
Butte died in California on June 13, 2025, at the age of 55.
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