Xylachlor is a selective herbicide, used to pre-emergently control annual grasses on cereals, wheat, soy and rice. It is an anilide and a (chloro)acetanilide. As of 2023 it is considered obsolete, but may still be in use.
It was manufactured by American Cyanamid under the "Combat" trademark, registered in August 1979 and expired (by non-renewal) in 1986.
Compared to the fellow acetanilides alachlor, acetochlor and metolachlor, xylachlor had the weakest control of pigweed and setaria, though the greatest selectivity. Xylachlor is also less detrimental to sorghum, but this is offset by the need for higher application rates to achieve similar weed control.
Xylachlor's safety is not well studied. Prediction software indicates that it may be a class 3 highly toxic compound, mutagen or carcinogen, although other software predictions disagree.
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