A venule is a very small vein in the microcirculation that allows blood to return from the capillary beds to drain into the venous system via increasingly larger veins. Post-capillary venules are the smallest of the veins with a diameter of between 10 and 30 (μm). When the post-capillary venules increase in diameter to 50μm they can incorporate smooth muscle and are known as muscular venules.
Short portal venules between the posterior pituitary and the anterior pituitary lobes provide an avenue for rapid hormonal exchange via the blood. Specifically within and between the pituitary lobes is anatomical evidence for confluent interlobe venules providing blood from the anterior to the neural lobe that would facilitate moment-to-moment sharing of information between lobes of the pituitary gland.
In contrast to regular venules, high endothelial venules are a special type of venule where the endothelium is made up of simple cuboidal cells. exit the blood stream and enter the lymph nodes via these specialized venules when an infection is detected. Compared with arterioles, the venules are larger with much weaker muscular coat. They are the smallest united common branch in the human body.
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