Top-down reading, is a part of reading science that explains the reader's psycholinguistic strategies in using grammatical and lexical knowledge for comprehension rather than linearly decoding texts.
Top-down proteomics, a method for protein analysis
Top-down effects, effects of population density on a resource in a soil food web
Neural top–down control of physiology
Top-down processing, in Pattern recognition (psychology)
Top-down investment analysis, an investment selection technique that evaluates macro factors (e.g., economy and industry) before micro factors (e.g., specific company)