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   » » Wiki: Thermolabile
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Thermolabile
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Thermolabile refers to a substance which is subject to decomposition or change in response to . This term is often used describe substances.

For example, many bacterial are thermolabile and can be easily inactivated by the application of moderate heat. are also thermolabile and lose their activity when the temperature rises. Loss of activity in such toxins and enzymes is likely due to change in the three-dimensional structure of the toxin during exposure to heat. In compounds, heat generated during grinding may lead to degradation of thermolabile compounds.

This is of particular use in testing function. This is done by intentionally creating which are thermolabile. Growth below the permissive temperature allows normal protein function, while increasing the temperature above the permissive temperature ablates activity, likely by denaturing the protein.

Thermolabile are also studied for their applications in techniques, such as PCR, where enzymes are necessary for proper DNA replication. Enzyme function at higher temperatures may be enhanced with , which opens up the possibility of using normally thermolabile enzymes in DNA replication.


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