A
SNPSTR is a compound
genetic marker composed of one or more SNPs and one
microsatellite (STR).
Autosome SNPSTRs, which contain an SNP and a microsatellite within 500 base pairs of one another, were discovered in 2002.
[Mountain J.L., Knight A., Jobin M., Gignoux C., Miller A., Lin A.A., Underhill P.A. SNPSTRs: empirically derived, rapidly typed, autosomal haplotypes for inference of population history and mutational processes. Genome Res. 2002;12:1766-1772.] More recently a database that contains all SNPSTRs in five model genomes, including human, has been created.
[AGRAFIOTI I AND STUMPF MPH (2007) "SNPSTR: a database of compound microsatellite-SNP markers" Nucleic Acids Research 35(Database issue): 71–75.]
Usage and importance
There has been widespread and growing interest in genetic markers suitable for drawing population genetic inferences about past demographic events and to detect the effects of selection. Single nucleotide polymorphisms (SNPs) and microsatellites (or short tandem repeats, STRs) have received great attention in the analysis of human population history, even though they have both disadvantages. It was thus suggested that the combination of these two markers could give rise to better conclusions.
See also
-
Population genetics
-
Biological database
-
Earth Human STR Allele Frequencies Database
-
STR analysis
-
STR multiplex system
-
Y-STR
