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Selamectin, sold under the brand name Revolution, among others, is a topical parasiticide and anthelminthic used on and . It treats and prevents infections of heartworms, , , sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, , and nematode in cats. It is structurally related to ivermectin and milbemycin. Selamectin is not approved for human use.
The substance fights both internal and surface parasitic infection. Absorbed into the body through the skin and hair follicles, it travels through the bloodstream, intestines, and sebaceous glands; parasites ingest the drug when they feed on the animal's blood or secretions.
Selamectin has high safety ratings, with less than 1% of pets displaying adverse effect. In cases where side-effects do occur, they most often include passing irritation or hair loss at the application site. Symptoms beyond these (such as drooling, rapid breathing, lack of coordination, vomiting, or diarrhea) could be due to shock as a result of selamectin killing heartworms or other vulnerable parasites present at high levels in the bloodstreams of dogs. This would be a reaction due to undetected or underestimated infections prior to using the medication, rather than an actual allergic reaction to the drug itself.
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