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Rufigallol or 1,2,3,5,6,7-hexahydroxy-9,10-anthraquinone is an organic compound with formula . It one of several hydroxyanthraquinones. It occurs naturally being derived from gallic acid.
The compound is soluble in dioxane, from which it crystallizes as red needles that sublime without melting at 365 °C. It can be obtained by treating gallic acid with concentrated sulfuric acid and then with sodium hydroxide. It is prepared by acid-catalyzed condensation of a pair of gallic acid molecules.
Rufigallol is particularly toxic to the parasite Plasmodium falciparum and has a synergy effect in combination with the antimalarial drug exifone, which has structural similarities to rufigallol.R. W. Winter, Kenneth A. Cornell, Linda L. Johnson, Marina Ignatushchenko, David J. Hinrichs, Michael K. Riscoe (1996), Potentiation of The Antimalarial Agent Rufigallol. Antimicrobial Agents and Chemotherapy, Vol. 40, No. 6, Pages 1408–1411 Online version accessed on 2010-02-01.
Rufigallol forms a crimson-colored complex with beryllium, aluminium, thorium, zirconium and hafnium, and this reaction has been used for the spot test and spectrophotometric determination of beryllium in low concentrations.M. A. Azim and A. A. Ayaz (1969), Spectrophotometric determination of beryllium. Microchimica Acta Volume 57, Number 1, pages 153-159
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