Product Code Database
Example Keywords: software -retro $13-179
   » » Wiki: Ranibizumab
Tag Wiki 'Ranibizumab'.
Tag

Related Products

Based on the best-selling horror action game Silent Hill stars Radha Mitchell (Man on Fire) as Rose a desperate other who takes her adopted daughter Sharon to the town of Silent Hill in an attempt to cure her of her ailment. After a violent car crash ..

It’s a college town, a mountain getaway for the quietly rich, where the average burglar alarm is set off by foraging wildlife. So when Edward Inman, the owner of Stoneleigh Sentinel, gets a latenight false alarm from the home of Doyle Cutler, one of ..

A heart-stopping supernatural thriller, PHANTOMS is the latest fright fest from AFFLECK acclaimed master of suspense, Dean Koontz. In the small town of Snowfield, 700 people are suddenly and inexplicably missing. Left behind are two sisters, the town sheri..

Join new 3D CGI animated Noddy and his friends in Toyland, a place where toys come to life and adventures never cease.In Hold on to your Hat, Noddy, Big-Ears' chimney is blocked and he's not very happy. To cheer his special friend up, Noddy decides to hold..

It is handy and reliable tool which enables you to navigate effectively in town or country. This supercompact clipper is aid for underwater navigation . The Suunto Clipper L/B NH compass can be clipped to a watch strap, the strap of a bag, the edge of your..

But when they arrive in town, the death of one of the villagers eclipses their original assignment. In the middle of a high-stakes horse race, a rider is stabbed in the back and thrown from his mount. Several people stand to gain from the rider's deat..

CLOSEOUTS . Terramarand#39;s All Sports High-Performance socks feature moisture-managing CoolMaxand#174; technology, a reinforced heel and toe, and a cushioned sole for long-lasting, everyday wear thatand#39;s comfortable on the trail or around town. Avail..

Language: ENGLISH Dimensions: 9.00 x 8.50 x 0.25 Weight: 0.30 ISBN-13: 9781897174814

Ranibizumab, sold under the brand name Lucentis among others, is a monoclonal antibody fragment (Fab) created from the same parent mouse antibody as . It is an that is approved to treat the "wet" type of age-related macular degeneration (AMD, also ARMD), diabetic retinopathy, and due to branch retinal vein occlusion or central retinal vein occlusion.

Ranibizumab was developed by and marketed by them in the United States, and elsewhere by , under the brand name Lucentis. Ranibizumab (Lucentis) was approved for medical use in the United States in June 2006, and in the European Union in January 2007.


Medical uses
In the United States, ranibizumab is for the treatment of neovascular (wet) age-related macular degeneration, macular edema following retinal vein occlusion, diabetic macular edema, diabetic retinopathy, and myopic choroidal neovascularization.

In the European Union, ranibizumab is indicated for the treatment of neovascular (wet) age-related macular degeneration, visual impairment due to diabetic macular edema, proliferative diabetic retinopathy, visual impairment due to macular edema secondary to retinal vein occlusion, and visual impairment due to choroidal neovascularisation.

It is used for age-related wet macular degeneration. Its effectiveness is similar to that of and . A 2023 systematic review update found that while ranibizumab and bevacizumab provide similar functional outcomes in diabetic macular edema, there is low-certainty evidence suggesting that ranibizumab is more effective in reducing central retinal thickness than bevacizumab.

Susvimo is a reformulation of ranibizumab suitable for injection via ocular implant. Susvimo was approved for medical use in the United States in October 2021.


Side effects
A 2014 Cochrane review did not find a difference between bevacizumab and ranibizumab in deaths or total severe side effects when used for macular degeneration. There, however, was not a lot of evidence, and thus this conclusion is not that certain.

Ranibizumab does appear to result in a lower risk of stomach and intestinal problems. It is also associated with a low rate of eye related side effects.

Serious adverse events related to the injection procedure occurred with an incidence rate of less than 1% and included , retinal detachment, and traumatic . Other serious ocular adverse events observed among ranibizumab-treated patients (incidence rate < 1%) included intraocular inflammation and blindness.

(2025). 9783852001968, Österreichischer Apothekerverlag.


Interactions
No significant interactions are known. Ranibizumab , Lexi-Drugs. Ranibizumab. Lexi-Comp, Inc.; 2007.


Pharmacology
Ranibizumab is a monoclonal antibody that inhibits by inhibiting vascular endothelial growth factor A, a mechanism similar to that of .


Society and culture

Legal status

Biosimilars
Byooviz was authorized for medical use in the European Union in August 2021. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

Ranibizumab-nuna (Byooviz) was approved for medical use in the United States in September 2021.

In India, received marketing approval for its biosimilar of Ranibizumab.

In June 2022, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Ranivisio, intended for the treatment of neovascular (wet) age-related macular degeneration, visual impairment due to macular edema or choroidal neovascularization, and proliferative diabetic retinopathy. The applicant for this medicinal product is Midas Pharma GmbH. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged. Ranivisio was authorized for medical use in the European Union in August 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

Ranibizumab-eqrn (Cimerli) was approved for medical use in the United States in August 2022.

In September 2022, the CHMP adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Ximluci, intended for the treatment of neovascular (wet) age-related macular degeneration, visual impairment due to diabetic macular edema, proliferative diabetic retinopathy, visual impairment due to macular edema secondary to retinal vein occlusion (branch RVO or central RVO), and visual impairment due to choroidal neovascularization. The applicant for this medicinal product is STADA Arzneimittel AG. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged. Ximluci was authorized for medical use in the European Union in November 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

In November 2023, the CHMP adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Rimmyrah, intended for the treatment of neovascular (wet) age-related macular degeneration, visual impairment due to diabetic macular edema, proliferative diabetic retinopathy, visual impairment due to macular edema secondary to retinal vein occlusion (branch RVO or central RVO), and visual impairment due to choroidal neovascularization. The applicant for this medicinal product is QILU PHARMA SPAIN S.L. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged. Rimmyrah is a biosimilar medicinal product that is highly similar to the reference product Lucentis (ranibizumab), which was authorized in the EU in January 2007. Rimmyrah was authorized for medical use in the European Union in January 2024.

In January 2024, Sandoz signed an agreement to acquire ranibizumab-eqrn, the biosimilar version of ranibizumab branded as Cimerli from Coherus BioSciences, Inc. for an upfront cash purchase payment of .

In July 2024, the CHMP adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Epruvy, intended for the treatment of neovascular (wet) age-related macular degeneration, visual impairment due to diabetic macular edema, proliferative diabetic retinopathy, visual impairment due to macular edema secondary to retinal vein occlusion and visual impairment due to choroidal neovascularization. The applicant for this medicinal product is Midas Pharma GmbH. Epruvy is a biosimilar medicinal product and is a duplicate of Ranivisio. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged. Epruvy was authorized for medical use in the European Union in September 2024.


Economics
Its effectiveness is similar to that of . Its rates of side effects also appear similar. However, ranibizumab typically costs $2,000 a dose, while the equivalent dose of bevacizumab typically costs $50.

Genentech offered secret rebates to about 300 ophthalmologists in an apparent inducement to get them to use more ranibizumab rather than the less expensive bevacizumab. In 2008, bevacizumab cost Medicare only $20 million for about 480,000 injections, while ranibizumab cost Medicare $537 million for only 337,000 injections. A small study showed no superior effect of ranibizumab versus bevacizumab in direct comparison. The initial results of the larger Comparison of Age-related Macular Degeneration Treatments Trials (CATT) found that the two drugs "had equivalent effects on visual acuity when administered according to the same schedule;" however, serious adverse events were more common in the bevacizumab arm of the trial.

According to a 2012 meta-analysis, the results of several subsequent head-to-head trials found that the two therapies performed equally at restoring visual acuity. A 2012 meta-analysis focused specifically on safety issues concluded that the rates of several adverse events were higher with bevacizumab, although the absolute rates of ocular serious adverse events were low with both therapies: ocular adverse events were about 2.8 times as frequent with bevacizumab than with ranibizumab.

Page 1 of 1
1
Post Comment
Font Size...
Font Family...
Font Format...

Page 1 of 1
1

Account

Social:
Pages:  ..   .. 
Items:  .. 

Navigation

General: Atom Feed Atom Feed  .. 
Help:  ..   .. 
Category:  ..   .. 
Media:  ..   .. 
Posts:  ..   ..   .. 

Statistics

Page:  .. 
Summary:  .. 
1 Tags
10/10 Page Rank
5 Page Refs