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Pyr-T

( N,n-dialkyltryptamines )

Use and effects
Interactions
Pharmacology

Pharmacodynamics

Chemistry

Analogues

History
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Receptor Serotonin Tihkal Tryptamine

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Pyr-T, also known as N, N-tetramethylenetryptamine or as 3-(2-pyrrolidinoethyl)indole, is a lesser-known serotonin receptor modulator of the tryptamine and pyrrolidinylethylindole families.

(1975). 9780856080111, Wright-Scientechnica. . ISBN 9780856080111

It is the cyclic compound derivative of diethyltryptamine (DET) in which the N, N-diethyl groups have been fused into a pyrrolidine ring.

Use and effects

In his 1997 book TiHKAL ( Tryptamines I Have Known and Loved), Alexander Shulgin reported neither the dose range nor the duration of the drug.

(1997). 9780963009692, Transform Press. . ISBN 9780963009692

However, individual experiments employed 25 to 50mg orally and 70mg smoked. Pyr-T produced effects including malaise, feeling sick, unpleasantness, salivation, muscle pain and , dizziness, feeling high, and uncomfortableness. effects, for instance visuals, were either absent or minor.

Interactions

Pharmacology

Pharmacodynamics

Pyr-T has been found to show affinity for serotonin receptors, including the serotonin 5-HT_1A, 5-HT_2A and 5-HT_2C receptors.

(2025). 9783662558782 . ISBN 9783662558782

Its affinities () for these receptors were 30nM for the serotonin 5-HT_1A receptor, 110nM for the 5-HT_2A receptor, and 750nM for the serotonin 5-HT_2B receptor. The affinities of pyr-T for the serotonin 5-HT_2A and 5-HT_2B receptors were similar to but slightly lower than those of dimethyltryptamine (DMT), whereas its affinity for the serotonin 5-HT_1A receptor was 5.7-fold higher than that of DMT and was intermediate between those of DMT and 5-MeO-DMT. The serotonin 5-HT_1A to 5-HT_2A receptor affinity ratios in the study were about 0.27 for pyr-T, 0.5 for 5-MeO-DMT, 1.4 for bufotenin, 2.3 for DMT, and 32 for psilocin.

Pyr-T has been found to produce behavioral changes in animal tests. It was described as being as potent as diethyltryptamine (DET) in rodents, cats, and primates, but that it also had a poor margin of activity relative to toxicity and was unlikely to be tested in humans. It has been found to produce hypolocomotion in rodents. Conversely, pyr-T (3mg/kg) failed to acutely produce the head-twitch response, a behavioral proxy of psychedelic drug effects, in rodents.

Chemistry

Pyr-T is a pyrrolidinylethylindole and a substituted tryptamine in which the amine moiety has been replaced with a pyrrolidine ring. It can be thought of as a cyclic compound derivative of diethyltryptamine (DET) in which the N, N- have been connected to form the pyrrolidine ring present in pyr-T.

Analogues

Derivatives of pyr-T include 4-HO-pyr-T, 5-MeO-pyr-T, and 4-F-5-MeO-pyr-T. Analogues of pyr-T include pip-tryptamine, 10,11-secoergoline (α, N-Pip-T), MPMI, and SN-22, among others.

History

Pyr-T was first characterized by Mitzal by 1962. Animal toxicity testing was later performed by Hunt and Brimblecombe by 1967. The effects of pyr-T in humans were described by Alexander Shulgin in his book TiHKAL in 1997.

Pyr-T

( N,n-dialkyltryptamines )

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Pyr-T ( N,n-dialkyltryptamines )

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Pyr-T

( N,n-dialkyltryptamines )