Protopanaxatriol ( PPT) is an organic compound that is an aglycone of , a group of steroid glycosides. It is a dammarane-type tetracyclic triterpene found in ginseng ( Panax ginseng) and in notoginseng ( Panax pseudoginseng).
In rats, the oral bioavailability is about 3.7% and the half-life is 0.80 hours (when given as a PPD-PPT mixture). PPT is unstable in acid, showing 40% degradation after 4 hours at 37°C both in pH 1.2 buffer solution and rat stomach contents. It is extensively metabolized in mice.
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