Propiconazole is a triazole fungicide, also known as a DMI, or demethylation inhibiting fungicide due to its binding with and inhibiting the 14-alpha demethylase enzyme from demethylating a precursor to ergosterol. Without this demethylation step, the ergosterols are not incorporated into the growing fungal cell membranes, and cellular growth is stopped.
Agriculture
Propiconazole is used agriculturally as a systemic fungicide on turfgrasses grown for seed and aesthetic or athletic value,
wheat,
mushrooms,
corn, wild rice,
,
almonds,
sorghum,
oats,
pecans,
apricots,
peaches,
nectarines,
plums,
prunes[ EXTOXNET] and lemons. It is also used in combination with
permethrin in formulations of wood preserver.
[ See entry for Complete Wood Preservative] Propiconazole is a mixture
[L. Toribio, M. J. del Nozal, J. L. Bernal, J. J. Jeménez und C. Alonso, J. Chromatography A 2004, 1046, 249-253.] of four
and was first developed in 1979 by Janssen Pharmaceutica.
[W. T. Thomson. 1997. Agricultural Chemicals. Book IV: Fungicides. 12th edition. Thomson Publications, Fresno, CA] Propiconazole exhibits strong anti-feeding properties against the keratin-digesting Australian carpet beetle
Anthrenocerus australis.
[Sunderland, M. R.; Cruickshank, R. H.; Leighs, S. J. (2014). "The efficacy of antifungal azole and antiprotozoal compounds in protection of wool from keratin-digesting insect larvae". Textile Research Journal 84 (9): 924–931. http://trj.sagepub.com/content/84/9/924]
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