Promazine (brand name Sparine among others),[ is used as a short-term add-on treatment for psychomotor agitation.]
It acts similar to chlorpromazine and causes sedation.
Promazine was approved for medical use in the United States in the 1950s, although it is no longer commercially available there.
Uses
Promazine is a short-term add-on treatment for psychomotor agitation.
Adverse effects
Common side effects include agitation, amenorrhoea, arrhythmias, constipation, drowsiness and dizziness, dry mouth, impotence, tiredness, galactorrhoea, gynaecomastia, hyperglycaemia, insomnia, hypotension, prolonged QT, seizure, tremor, vomiting and weight gain, among others.
Overdose
In overdose, it may cause hypotension, hypothermia, tachycardia, and arrhythmia.
Sudden death may occur, although rare.
Other animals
Promazine, given as promazine hydrochloride, is one of the primary tranquilizers used by veterinarians as a pre-anaesthesia injection in horses.
Synthesis
