Phloretin is a dihydrochalcone, a type of natural phenol. It can be found in apple tree leaves
Metabolism
In rats, ingested
phlorizin is converted into phloretin by hydrolytic enzymes in the small intestine.
Phloretin hydrolase hydrolyses phloretin into
phloretic acid and
phloroglucinol.
Pharmacological research
In an animal model, phloretin inhibited
active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its
glycoside phlorizin.
An important effect of this is the inhibition of glucose absorption by the small intestine
[ and the inhibition of renal glucose reabsorption.][ Phloretin also inhibits a variety of .]
Nanoparticle synthesis
Phloretin functionalized gold-nanoparticles (Pht-GNPs) were synthesized using a single-step synthesis method and tested for its anticancer activity. Pht-GNPs showed significant cancer cell toxicities compared to free phloretin.
Glycosides
-
Phlorizin is the 2'-glucoside of phloretin
-
Naringin dihydrochalcone is a diglycoside of phloretin
See also
