Oxiconazole

 ( Chlorobenzene Derivatives ) 

Oxiconazole (trade names Oxistat in the US, Oxizole in Canada) is an antifungal medication typically administered in a cream or lotion to treat skin , such as athlete's foot, jock itch and ringworm. It can also be prescribed to treat the skin rash known as tinea versicolor, caused by systemic yeast overgrowth ( Candidiasis spp.).

It was patented in 1975 and approved for medical use in 1983.

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Synthesis

Treatment of the ketone (1) with hydroxylamine gives the oxime (2), which is alkylated with 2,4-dichlorobenzyl chloride (3) in the presence of the strong base sodium hydride to give oxiconazole.Georg Mixich, Kurt Thiele, (1985 to Siegfried Aktiengesellschaft).

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See also

• Fluconazole

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External links

• MedlinePlus - Oxiconazole

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