Product Code Database
Methylglyoxal ( MGO) is the organic compound with the formula CH3C(O)CHO. It is a reduced derivative of pyruvic acid. It is a reactive compound that is implicated in the biology of diabetes. Methylglyoxal is produced industrially by degradation of carbohydrates using overexpressed methylglyoxal synthase.
Since methylglyoxal is highly cytotoxic, several detoxification mechanisms have evolved. One of these is the glyoxalase system. Methylglyoxal is detoxified by glutathione. Glutathione reacts with methylglyoxal to give a hemithioacetal, which converted into S--lactoyl-glutathione by glyoxalase I. This thioester is hydrolyzed to Lactic acid by glyoxalase II.
DNA damages are induced by reactive carbonyl group, principally methylglyoxal and glyoxal, at a frequency similar to that of DNA oxidation.Richarme G, Liu C, Mihoub M, Abdallah J, Leger T, Joly N, Liebart JC, Jurkunas UV, Nadal M, Bouloc P, Dairou J, Lamouri A. Guanine glycation repair by DJ-1/Park7 and its bacterial homologs. Science. 2017 Jul 14;357(6347):208-211. doi: 10.1126/science.aag1095. Epub 2017 Jun 8. PMID 28596309 Such damage, referred to as DNA glycation, can cause mutation, breaks in DNA and cytotoxicity. In humans, a protein DJ-1 (also named PARK7), has a key role in the repair of glycated DNA bases.
Research suggests that methylglyoxal contained in honey does not cause an increased formation of advanced glycation end products (AGEs) in healthy persons.
Biomedical aspects
Due to increased blood glucose levels, methylglyoxal has higher concentrations in diabetics and has been linked to arterial atherogenesis. Damage by methylglyoxal to low-density lipoprotein through glycation causes a fourfold increase of atherogenesis in diabetics. Methylglyoxal binds directly to the nerve endings and by that increases the chronic extremity soreness in diabetic neuropathy. Spektrum: Diabetische Neuropathie: Methylglyoxal verstärkt den Schmerz: DAZ.online. Deutsche-apotheker-zeitung.de (2012-05-21). Retrieved on 2012-06-11.
Occurrence, other
Methylglyoxal is a component of some kinds of honey, including manuka honey; it appears to have activity against E. coli and S. aureus and may help prevent formation of formed by P. aeruginosa.
See also
|
|
