Product Code Database
Macrogol is the international nonproprietary name used for polyethylene glycol ( PEG) as a medication ingredient. It is usually followed by a number indicating the average molecular weight, indicating the length of the polymer of the specific molecule in use. Macrogol is used as a laxative to treat constipation in children and adults. (2025). 9780857113382, Pharmaceutical Press. ISBN 9780857113382 It is taken by mouth. Benefits usually occur within three days. It is also used as an excipient. It is also used to clear the before a colonoscopy, when the onset of the laxative effect is more rapid, typically within an hour.
Side effects may include flatulence, abdominal pain, and nausea. Rare but serious side effects may include an abnormal heartbeat, , and kidney problems. Use appears to be safe during pregnancy. It is classified as an osmotic laxative: It works by increasing the amount of water in the Human feces.
Macrogol came into use as a bowel prep in 1980 and was approved for medical use in the United States in 1999.
In those with chronic constipation it works better than lactulose.
Popular types include: macrogol 3350, macrogol 4000, and macrogol 6000. The number represents the molecular weight. Combining different molecular weights provides some control over the consistency.
For example, PEG-2000 is one of the excipients in the Moderna COVID-19 vaccine.
The doses of macrogol as an excipient are too low to have relevant contraindications.
Allergy to macrogol is rare, and usually appears as an allergy to an increasing number of seemingly unrelated products, including cosmetics, drugs that use it as an excipient, and peri-procedural substances such as ultrasound gel.
Polyethylene glycol-electrolyte solution is a fixed-dose combination medication sold under various brand names in the US, including Colyte, Gavilyte, Golytely, Nulytely, Moviprep, and Trilyte. Brand names available in the UK include Cosmocol, Klean-Prep, Laxido, Molaxole, Movicol, Plenvu, Transisoft, and Vistaprep. , polyethylene glycol 3350 is available in the US as a combination with sodium sulfate, potassium chloride, magnesium sulfate, and sodium chloride and sold under the brand name Suflave. It is indicated for cleansing of the colon in preparation for colonoscopy in adults.
(2025). 9780323401630, Elsevier Health Sciences. ISBN 9780323401630 (2025). 9781437735703, Elsevier Health Sciences. ISBN 9781437735703 It is available as a generic medication and over the counter. In 2022, it was the 209th most commonly prescribed medication in the United States, with more than 1million prescriptions. It is also formulated together with electrolytes. (2025). 9780444537164, Elsevier. ISBN 9780444537164 In 2022, the combination with electrolytes was the 282nd most commonly prescribed medication in the US, with more than 600,000 prescriptions.
Medical uses
Constipation
Macrogol 3350, often in combination with , is used for short-term relief of constipation as well as for long-term use in constipation of various causes, including in people with multiple sclerosis or Parkinson's disease as well as constipation caused by pharmaceutical drugs such as and . Whole bowel irrigation with macrogol is part of the bowel preparation before surgery or colonoscopy. Limited data also support its use for the treatment of fecal impaction.
Excipient
Macrogol is used as an excipient in pharmaceutical products. Lower-molecular-weight variants are used as solvents in oral liquids and soft capsules, whereas solid variants are used as ointment bases, tablet binders, , and .
PEGylation
Macrogols are also attached to biopharmaceutical drugs to slow down their degradation in the human body and increase their duration of action, as well as to reduce immunogenicity. This process is called PEGylation.
Contraindications
Contraindications for macrogol taken orally as a laxative are intestinal perforation, bowel obstruction, ileus, inflammatory bowel diseases, and toxic megacolon.
Adverse effects
Oral macrogol is generally well tolerated. Possible side effects include headache, bloating, nausea, allergies, and electrolyte imbalance, mainly hypokalaemia (low blood potassium levels) and hyperkalaemia (high blood potassium levels). Hyperkalaemia is not an effect of macrogol itself but of potassium salts which are usually part of macrogol formulations.
Interactions
The interaction potential is low. Absorption of other pharmaceutical drugs can be reduced because oral macrogol accelerates intestinal passage, but this is seldom clinically relevant. For antiepileptic drugs, such a mechanism has been described in rare cases.
Pharmacology
Mechanism of action as a laxative
Macrogol is an osmotically acting laxative; that is, an inert substance that passes through the gut without being absorbed into the body. It relieves constipation because it causes water to be retained in the bowel instead of being absorbed into the body. This increases the water content and volume of the human feces in the bowel, making them softer and easier to pass, as well as improving gut motility.
Chemistry
Available forms
When sold for gut cleansing (and as a laxative), it is usually in combination with salts such as sodium bicarbonate, sodium chloride and potassium chlorideeg. to help mitigate the possibility of electrolyte imbalance and dehydration. Brand names include Cosmocol, Cololyt, Glycoprep, Laxido, Miralax, Molaxole, Movicol, and Osmolax.
Research
PEGylation
When attached to various biopharmaceutical medications (which are proteins), macrogol results in a slowed clearance of the carried protein from the blood. This makes for a longer-acting medicinal effect and reduces toxicity, and it allows for longer dosing intervals. It also reduces the proteins' immunogenicity. Examples for PEGylated proteins include peginterferon alfa-2a and -2b, which are used to treat hepatitis C, pegfilgrastim, which is used to treat neutropenia, and pegloticase for the treatment of gout.
Nerves and spinal cords
There is evidence demonstrating PEG-induced repair of specific nerve cells in animal models:
Cancer prevention
Other
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