Kallidin belongs to the family , which are the .
/ref> yields the potently bioactive bradykinin molecule.
Effects of Kinins
Kallidin is a bioactive
kinin peptide formed in response to injury from
kininogen precursors through the action of
.
Like all kinins, kallidin, the deca-peptide, plays an important role in several body pathologies. Kinins can regulate the blood pressure by increasing the level of
Antihypotensive.
They can also bind to the B
1 and B
2 cell surface receptors, which are G-protein coupled receptors.
The mediation of the B
1 receptors by des-Arg kinins as
can be expressed in several medical issues, such as cancer and trauma.
By binding to the B
2 receptors, kinins, endogenous agonists, can regulate the
Vasodilation and bronchioconstriction.
Chemical Mechanisms
Since kinins are peptides, they can be cleaved by the
peptidases. Peptidases such as the serine peptidases, carboxypeptidase N and carboxypeptidase M cleave kinins into des-Arg-bradykinin and Lys-des-Arg-bradykinin.
Clarification
Kallidin is identical to
bradykinin with an additional
lysine residue added at the
N-terminal end and signals through the bradykinin receptor.
Despite exhibiting similar functions and reactivities, kinins can be differentiated by combining an amino-terminal-directed radioimmunoassay with a carboxy-terminal-directed radioimmunoassay in combination with HPLC.
See also
