Jasplakinolide

 ( Sponge Toxins ) 

Jasplakinolide is a naturally occurring cyclo-depsipeptide. It was first isolated from a species of marine sponge named Jaspis johnstoni. It is permeable to the cell membrane meaning that it is able to cross the membrane.

Once it crosses the cell membrane, it is a potent inducer and stabilizer of Microfilament meaning that it rapidly stabilizes pre-existing filaments and Polymerization the protein actin. It also inhibits the disassembly of theses filaments. When doing this, it competes with phalloidin making it unable to bind with F-actin.

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Applications Jasplakinolide is potentially important in medical applications showing anti-cancer, Fungicide and antiproliferative properties. It also has important scientific applications for the study of , and actin filaments.

Categories: Sponge Toxins, Cytoskeleton Proteins, Depsipeptides, Indoles, Bromoarenes, Bromine-containing Natural Products, 4-hydroxyphenyl Compounds

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