Isopropoxate is an anesthetic drug related to etomidate, which has been sold as a designer drug as an active ingredient in e-cigarette liquids marketed under names such as space oil or kpods. While the related n-propyl ester propoxate has been known since the 1970s, the isopropyl ester isopropoxate is a novel compound which was previously unknown prior to its detection as a designer drug in China in January 2024. It was added to the controlled drug list in China in July 2024, following which a number of other etomidate analogues have continued to appear. Substance details: Isopropoxate. UNODC, 2025
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