Hydroxydione

 ( 5β-pregnanes ) 

Hydroxydione, as hydroxydione sodium succinate (, , ) (brand names Viadril, Predion, and Presuren),

(2005). 9788122415650, New Age International. . ISBN 9788122415650

William Andrew Publishing (2013). 9780815518563, Elsevier. . ISBN 9780815518563

also known as 21-Hydroxy-5β-pregnane-3,20-dione, is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued due to incidence of thrombophlebitis in patients.

(2013). 9781461484417, Springer Science & Business Media. . ISBN 9781461484417

It was introduced in 1957, and was the first neuroactive steroid general anesthetic to be introduced for clinical use, an event which was shortly preceded by the observation in 1954 of the sedative properties of progesterone in mice.

(2013). 9781483272993, Elsevier Science. . ISBN 9781483272993

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Chemistry

Related compounds include alfadolone, alfaxolone, dihydrodeoxycorticosterone, ganaxolone, minaxolone, pregnanolone, and renanolone.

Categories: 5β-pregnanes, Primary Alcohols, Diketones, Gabaa Receptor Positive Allosteric Modulators, General Anesthetics, Neurosteroids

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