Hydrophobia may refer to:
Science
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Aquaphobia, an irrational fear of water
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Hydrophobe, the chemical property of a molecule that is seemingly repelled from a mass of water
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Rabies, historically referred to as hydrophobia, a viral disease that causes encephalitis in humans and other mammals
Art, entertainment, and media
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Hydrophobia (video game), a 2010 game developed and published by Dark Energy Digital
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Hydrophobia, a Hungarian disk magazine
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"Hydrophobia", the 13th track on the Risk of Rain 2 soundtrack