Product Code Database
Harmane (harman) is a heterocyclic amine and β-carboline found in a variety of foods including coffee, sauces, and cooked meat. It is also present in Tobacco smoking.
Harmane is related to other alkaloids, harmine and harmaline, found in 1837 in the plant Peganum harmala. The name derives from the Arabic word for the plant, rtl=yes (ḥarmal).
In humans, harmane is a potent tremor-producing neurotoxin. Harmane has been found to inhibit the early stages of the growth of the malaria parasite in the gut of infected by the bacterium Delftia tsuruhatensis, and can be absorbed by the mosquitoes upon contact.
| + Plant sources |
| Coffea arabica |
| Nicotiana tabacum |
| Camellia sinensis |
In 1962, Poindexter et al. found that there was very little harmane in tobacco, but a significant amount in tobacco smoke. They showed that it is produced from tryptophan by the heat of burning the tobacco.
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