Guineesine

 ( Alkaloids Found In Plants ) 

Guineesine (or guineensine) is a compound isolated from long pepper ( Piper longum) and black pepper ( Piper nigrum).

It was first isolated, studied and named from Piper guineense.OKOGUN, J.I. and Ekong, D.E.U. 1974 Extracts from the Fruits of the Piper guineense. Schum and Thonn. J. Chem. Soc. Perkin Transactions I, 1974, 2195-2198.Okwute, S.K. OKOGUN, J.I. and Okorie, D.A. 1984 Revised Structure and Synthesis of Piperolein acids; Guineensine and Wisanine from Piper guineense, TETRAHEDRON, 40, 2541-2545.

---

Research Guineensine inhibits the cellular reuptake of anandamide and 2-arachidonoylglycerol in a mouse model (EC₅₀ = 290 nM). This causes an increase in the activity of the two which are classified as endogenous cannabinoids.

Guineesine can dose-dependently produce Cannabinoidergic effects in a mouse model which are indicated by potent Catatonia, analgesic, Hypolocomotion and Hypothermia effects. In addition, the analgesic and catatonic effects were reversed by the cannabinoid receptor type 1 (CB1) inverse agonist rimonabant.

Guineesine is also a monoamine oxidase inhibitor (MAOI) in vitro (IC₅₀ = 139.2 μM).

Post Comment