Product Code Database
Gramine (also called donaxine) is a naturally occurring indole alkaloid present in several plant species. Gramine may play a defensive role in these plants, since it is toxic to many organisms.
Gramine has been found to act as an agonist of the adiponectin receptor 1 (AdipoR1).
The LD50 of gramine is 44.6 mg/ kg iv in mice and 62.9 mg/ kg iv in rats. Numerous studies have been done on the toxicity of gramine and tryptamines to insects harmful to crops in order to assess their potential use as an insecticide.
Recent toxicity evaluations show Gramine to be relatively low toxicity in humans, and to have anti-mutagenic and potential neuroprotective action, as a widely found alkaloid present in Oats and Barley. "Safety evaluation of an oat grain alkaloid gramine by genotoxicity assays"
There are numerous recent studies on the potential health benefits of Gramine.
|
|
