Etodolac is a nonsteroidal anti-inflammatory drug (NSAID).
It was patented in 1971 and approved for medical use in 1985.
Medical uses
NSAIDs are used for the management of mild to moderate pain, fever, and
inflammation. They work by reducing the levels of
, which are chemicals that are responsible for pain and the fever and tenderness that occur with inflammation. Etodolac blocks the
cyclooxygenase (abbrev. COX) enzymes which form
, resulting in lower concentrations of
. As a consequence, inflammation, pain and fever are reduced.
Etodolac is 179 times more selective at blocking COX-2 than COX-1.
In the UK, Etodolac is licensed for the Therapy of inflammation and pain caused by osteoarthritis and rheumatoid arthritis.[ BNF 55 - Etodolac]
Interactions
Etodolac should be avoided by patients with a history of
asthma attacks,
Urticaria, or other
Allergy to
aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with
peptic ulcer disease or poor
Renal physiology, since this medication can worsen both conditions. Etodolac is used with caution in patients taking blood thinning medications (
), such as
warfarin (Coumadin), because it increases the risk of
bleeding. Patients taking both lithium and etodolac may develop toxic blood lithium levels. Additionally, etodolac has been found to interact with certain anti-depressant medications, such as
sertraline or
fluoxetine, which can increase risks of stroke, heart attack, and other cardiovascular conditions. Patients also taking
ciclosporin (Sandimmune) can develop kidney toxicity. Use in children has not been adequately studied. Etodolac is not habit-forming. NSAIDs should be discontinued prior to
elective surgery because of a mild interference with
clotting that is characteristic of this group of medicines. Etodolac is best discontinued at least four days in advance of surgery. Etodolac metabolites may also cause a false positive bilirubin result on a urinalysis test.
[2]
Pregnancy and nursing
Etodolac is generally avoided during
pregnancy and
Breast feeding. NSAIDs may cause adverse cardiovascular effects in the
fetus during pregnancy.
In October 2020, the U.S. Food and Drug Administration (FDA) required the Drug labelling to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.[ ][ ]
Brand names
Etodolac is manufactured by Almirall Limited under the brand name Lodine SR
and by Meda Pharmaceuticals under the name Eccoxolac.
Generic etodolac is also available.
Etodolac is also sold under several brand names, including:
-
Etogesic (India)
-
Etova (India)
-
Dualgan / Sodolac (Portugal)
-
Etodin (South Korea)
-
Etofree (India)
-
Etopan (Israel)
-
Flancox
-
Haipen (Japan)
-
Lodine (France, Switzerland, United States)
-
Proxym (S Etodolac) (India)
-
Dolarit, Edolar, Etol (Turkey)
-
Lonene (Indonesia, Taiwan)
-
Etodine (Egypt)
-
Etodin Fort (Bulgaria)
External links
