Product Code Database
Enflurane (2-chloro-1,1,2-trifluoroethyl difluoromethyl ether) is a halogenated ether. Developed by Ross Terrell in 1963, it was first used clinically in 1966. It was increasingly used for inhalational anesthesia during the 1970s and 1980s but is no longer in common use. (2025). 9781437716795 ISBN 9781437716795
Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature.
| Boiling point at 1 atm | 56.5 °C |
| MAC | 1.68 |
| Vapor pressure at 20 °C | 22.9 kPa (172 torr) |
| 1.9 | |
| Oil:gas partition coefficient | 98 |
Enflurane also lowers the threshold for seizures, and should especially not be used on people with epilepsy. Like all potent inhalation anaesthetic agents it is a known trigger of malignant hyperthermia.
Like the other potent inhalation agents it relaxes the uterus in pregnant women which is associated with more blood loss at delivery or other procedures on the gravid uterus.
The obsolete (as an anaesthetic) agent methoxyflurane had a nephrotoxic effect and caused acute kidney injury, usually attributed to the liberation of fluoride ions from its metabolism. Enflurane is similarly metabolised but the liberation of fluoride results in a lower plasma level and enflurane related kidney failure seemed unusual if seen at all.
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