Ecdysteroid

 ( Steroids ) 

Ecdysteroids are arthropod that are mainly responsible for Moulting (ecdysis), development and, to a lesser extent, reproduction; examples of ecdysteroids include ecdysone, 20-hydroxyecdysone (ecdysterone), turkesterone and 2-deoxyecdysone. These compounds are synthesized in arthropods from dietary cholesterol via the Halloween genes of cytochrome P450 enzymes.

Compounds with ecdysteroid activity in arthropods are not only produced by these animals ( zooecdysteroids). also appear in many plants mostly as a protection agents (toxins or ) against herbivore insects. Fungi also produce a handful of mycoecdysteroids.

In addition, synthetic ecdysteroid pesticides such as methoxyfenozide have been produced.

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Mammals Ecdysterone has been tested on mammals due to the interest in its potential hypertrophic effect. It has been found to increase hypertrophy in rats at a similar level to some anabolic androgenic steroids and SARMs. This is proposed to be through increase of Calcium leading to activation of Akt and protein synthesis in skeletal muscles. A newer study points to estrogen receptor beta.

20-hydroxyecdysone is a human drug candidate.

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See also

• Ecdysone receptor

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External links

• Ecdybase, The Ecdysone Handbook - a free online ecdysteroids database

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