Duclos is a surname. Notable people with the surname include:
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Brigitte Duclos (born 1964), Australian television and radio presenter
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Charles Pinot Duclos (1704–1772), a French author
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Gilbert Duclos-Lassalle (born 1954), a former French professional road racing cyclist
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Hervé Duclos-Lassalle (born 1979), a French professional road racing cyclist
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Jacques Duclos (1896–1975), a French Communist politician
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Jean-Yves Duclos (born 1965), a Canadian Liberal politician
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Louis Duclos (born 1939), a Liberal party member of the Canadian House of Commons
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Michelle Duclos (1939–2017), a Canadian television performer and supporter of the Front de Libération du Québec
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Pierre Duclos, a French curler
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Pierre-Ludovic Duclos (born 1986), a Canadian former professional tour tennis player
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Samuel Cottereau du Clos (1598–1685), French chemist
