Dithioerythritol ( DTE) is a sulfur containing sugar alcohol derived from the corresponding 4-carbon monosaccharide erythrose. It is an epimer of dithiothreitol (DTT). The molecular formula for DTE is C4H10O2S2.
Reduction with DTE is slower than with DTT. This is presumably because the orientation of the OH groups in its cyclic disulfide bond form (oxidized form) is less stable due to greater steric effects than their orientation in the disulfide-bonded form of DTT. In the disulfide-bonded form of DTT, these hydroxyl are trans to each other, whereas they are cis to each other in DTE.
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