Deracoxib

 ( Dog Medications ) 

Deracoxib (trade name Deramaxx) is a nonsteroidal anti-inflammatory drug (NSAID) of the coxib class, used in dogs to treat pain associated with osteoarthritis, or to prevent pain following orthopedic or dental surgery. It is available as beef-flavored tablets.

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Medical uses Deracoxib is used in dogs for the control of pain and inflammation associated with osteoarthritis and for the prevention of pain following orthopedic surgery or dental procedures.

(2025). 9780323222143, Elsevier Mosby. ISBN 9780323222143

In cats, the use of deracoxib is not recommended.

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Contraindications Deracoxib is contraindicated for treatment of dogs with hypersensitivity to deracoxib or other , and dogs with gastro-intestinal ulcers, renal disease, hepatic disorders, hypoproteinemia, dehydration, or cardiac disease.

Dogs with renal disease may need dose adjustment (if the benefits of the medication outweigh the risks), while those on concurrent diuretic therapy are at increased risk for NSAID toxicity and should not be given this medication.

The concurrent use of deracoxib with steroids or other NSAIDs should be avoided. The safety of deracoxib has not been established in pregnant or nursing dogs or in dogs younger than 4 months of age.

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Adverse effects The most common adverse effects of treatment with deracoxib are vomiting, anorexia, lethargy and depression. Other adverse effects of deracoxib are caused by its effects on the gastrointestinal tract, and include erosions or ulcerations of the lining of the stomach or intestines.

(2025). 9780323244862, Elsevier Health Sciences. ISBN 9780323244862

Serious adverse effects, including ulcers which perforate the gastrointestinal tract, have occurred in dogs administered higher than recommended doses of deracoxib, or dogs administered deracoxib at the same time as (or soon after) other or corticosteroid medications.

(2025). 9781455707171, Elsevier. ISBN 9781455707171

Documented adverse side effects include serious and sometimes fatal organ system damage or failure. Other side effects include increase in drinking or urination, jaundice, bloody or black stools, pale gums, hot spots, increased respiration (fast or heavy breathing), incoordination, and behavior changes.

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Pharmacology Deracoxib is a coxib class nonsteroidal anti-inflammatory drug (NSAID). Like other NSAIDs, its effects are caused by inhibition of cyclooxygenase (COX) enzymes.

(2025). 9781118685907, John Wiley & Sons. ISBN 9781118685907

At the doses used to treat dogs, deracoxib causes greater inhibition of than of , but at doses twice those recommended for use in dogs, deracoxib significantly inhibits as well.

In dogs, the half-life of deracoxib at the recommended dose is three hours.

(2025). 9780702028588, Saunders/Elsevier. . ISBN 9780702028588

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Society and culture

In the U.S., deracoxib was first approved for use in dogs in 2002, under the trade name Deramaxx chewable tablets, sold by Novartis Animal Health.

Categories: Dog Medications, Pyrazoles, Cox-2 Inhibitors, Drugs Developed By Novartis, Nonsteroidal Anti-inflammatory Drugs, Difluoromethyl Compounds, Sulfonamides, Fluoroarenes

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