Product Code Database
Chloroxylenol, also known as para-chloro- meta-xylenol ( PCMX), is a chlorine substituted phenol with a white to off-white appearance and a phenolic odor.
The discovery of chloroxylenol was the result of efforts to produce improved antiseptics that began at the end of the 1800s, when scientists gradually realized that more substituted and more Lipophilicity phenols are less toxic, less irritant and more powerful. First synthesized in Germany in 1923, it was borne out of the study of coal tar components that began a decade earlier.
The World Health Organization lists a 4.8% solution of chloroxylenol as an essential medicine. When diluted, this chloroxylenol preparation is used as an antiseptic and disinfectant, and for skin disinfection. Diluted with alcohol, it is suitable for disinfecting medical instruments.
The use of chloroxylenol has been increasing due to the removal of hexachlorophene and later triclosan and others from world markets. It is currently used for control of bacteria, algae, and fungi in:
Chloroxylenol may also be harmful to smaller vertebrates, especially cats. Phenolic compounds are of particular concern to felines because cats are unable to fully metabolize them. A cat may swallow the product by licking its paws after it has come into contact with it. Products containing chloroxylenol such as Dettol have been previously administered with a spray bottle on unwanted pests or invasive species such as cane toads, which die shortly after being sprayed with the phenolic compound. The use of chloroxylenol-containing Dettol as an agent for pest control was banned in Western Australia by the Department of Environment and Conservation in 2011.
United States
Chloroxylenol was first introduced to the United States in 1959. Chloroxylenol containing products must not be used in any manner that allows contamination of water.
EU
The European Union allows chloroxylenol in cosmetics up to 0.5%.
Antimicrobial properties
Chloroxylenol is most effective against gram-positive bacteria. It works by disruption of the cell wall and stopping the function of enzymes. It is less effective than some other available agents.
Testing has shown products containing chloroxylenol effective against the SARS-CoV-2 virus and .
Toxicology
Chloroxylenol is generally slightly to moderately toxic to (but causes severe eye irritation), is practically non-toxic to birds, toxic to fish, and moderately toxic to freshwater invertebrates. The European Union considers it to be a skin sensitizer.
Related compounds
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