Chloropyridines are a group of
consisting of a
pyridine ring with
chlorine atoms as substituents.
Chloropyridines include:
-
2-Chloropyridine
-
3-Chloropyridine
-
4-Chloropyridine
-
2,6-Dichloropyridine
Production
halogenation of pyridine with chlorine gas above 270 °C gives a mixture of 2-chloropyridine and 2,6-dichloropyridine.
2- and 4-chloropyridine are prepared from the corresponding using phosphoryl chloride.
Uses
Chloropyridines are important intermediates to pharmaceuticals and
.
A major use of 2-chloropyridine is the production of production of the
fungicide pyrithione. Reaction of 4-chloropyridine with thioglycolic acid gives pyridylmercaptoacetic acid, a step in the production of
cephalosporin antibiotics.
See also
