Cefprozil is a second-generation cephalosporin antibiotic.
Adverse effects
Although there is a widely quoted cross-allergy risk of 10% between cephalosporins and penicillin, research has shown no increased risk for cross-allergy for cefprozil and several other second-generation or later cephalosporins.
The most common side effects were increased hepatic lab values (including AST and ALGT), dizziness, eosinophilia, diaper rash and superinfection, genital pruritus, vaginitis, diarrhea, nausea, vomiting, and abdominal pain.
Spectrum of bacterial susceptibility and resistance
Currently, bacteria like
Enterobacter aerogenes,
Morganella morganii and
Pseudomonas aeruginosa are resistant to cefprozil, while
Salmonella enterica serotype Agona and
streptococci are susceptible to cefprozil. Some bacteria like
Brucella abortus,
Moraxella catarrhalis and
Streptococcus pneumoniae have developed resistance towards cefprozil in varying degrees. Detailed minimum inhibition concentration information is given by the Cefprozil Susceptibility and Resistance Data sheet.
Synthesis
Displacement of the allylic chloride in intermediate (
1) with triphenylphosphine gives the phosphonium salt (
2). This functionality is then converted to its
ylide; condensation with
acetaldehyde then leads to the
vinyl group derivative (
3); deprotection then gives cefprozil. Semisynthetic oral cephalosporin consisting of ~90:10 Z/E isomeric mixture.
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