Butalbital is a barbiturate with an intermediate duration of action. Butalbital is often combined with other medications, such as paracetamol (acetaminophen) (as butalbital/acetaminophen) or aspirin, for the treatment of pain and headache. The various formulations combined with codeine are FDA-approved for the treatment of . Butalbital has the same chemical formula as talbutal but a different structure—one that presents as 5-allyl-5-isobutylbarbituric acid.[DE Patent 526854]
Available forms
Combinations include:
-
Butalbital/acetaminophen, Butalbital and acetaminophen (paracetamol), (trade names: Axocet, Bucet, Bupap, Cephadyn, Dolgic, Phrenilin, Forte, Sedapap)
-
Butalbital/paracetamol/caffeine (trade names: Fioricet, Esgic, Esgic-Plus, Orbivan, Fiormor, Fiortal, Fortabs, Laniroif)
-
Butalbital/caffeine/codeine (trade name: Fioricet#3 with Codeine)
-
Butalbital/aspirin (trade name: Axotal)
-
Butalbital/aspirin/caffeine (trade name: Fiorinal)
-
Butalbital/aspirin/caffeine/codeine (trade name: Fiorinal#3 with Codeine)
-
Ergotamine/caffeine/butalbital/belladonna alkaloids (trade name: Cafergot-PB)
Contraindications
There are specific treatments which are appropriate for targeting
and headaches.
[, which cites
] Butalbital is not recommended as a first-line treatment because it impairs alertness, brings risk of dependence and addiction, and increases the risk that episodic headaches will become chronic.
[, which cites
] When other treatments are unavailable or ineffective, butalbital may be appropriate if the patient can be monitored to prevent the development of chronic headache.
Side effects
Side effects for butalbital is usually well tolerated. Commonly reported side effects for butalbital, some of which tend to subside with continued use, include:
Rare side effects include Stevens–Johnson syndrome, an adverse reaction to barbiturates, and anaphylaxis.
The risk and severity of all side effects is greatly increased when butalbital are combined with other sedatives (e.g., alcohol, , , ). Butalbital when taken with sedatives can cause life-threatening respiratory depression and death. Inhibitors of the hepatic enzyme CYP3A4 may also increase the risk, severity, and duration of side effects, many drugs inhibit this enzyme as do some foods such as grapefruit and the blood orange.
Butalbital can cause dependence or addiction.
Interactions
Mixing with alcohol, benzodiazepines, and other
increases the risk of intoxication, increases respiratory depression, and increases liver toxicity when in combination with paracetamol (acetaminophen). Use of butalbital and alcohol, benzodiazepines, and other depressants can contribute to coma, and in extreme cases, fatality.
External links
