Bufadienolide

 ( Bufanolides ) 

Bufadienolide is a chemical compound with steroid structure. Its derivatives are collectively known as bufadienolides, including many in the form of bufadienolide glycosides (bufadienolides that contain structural groups derived from sugars). These are a type of cardiac glycoside, the other being the cardenolide glycosides. Both bufadienolides and their glycosides are toxic; specifically, they can cause an atrioventricular block, bradycardia (slow heartbeat), ventricular tachycardia (a type of rapid heartbeat), and possibly lethal cardiac arrest.

---

Etymology The term derives from the toad genus Bufo that contains bufadienolide glycosides, the suffix -adien- that refers to the two double bonds in the lactone ring, and the ending -olide that denotes the lactone structure. Consequently, related structures with only one double bond are called bufenolides, and the saturated equivalent is bufanolide.IUPAC Recommendations 1999: Revised Section F: Natural Products and Related Compounds

---

Classification According to MeSH, bufadienolides and bufanolides are classified as follows:

• Polycyclic compounds
• Cardiac glycosides
• Bufanolides (includes bufenolides, bufadienolides, bufatrienolides)
• Proscillaridin
• Daigremontianin

---

Further reading

• Steyn, PS; Heerden, FR van (1998). Bufadienolides of plant and animal origin, Natural Product Reports, 15(4):397-413.

Post Comment