Androstanedione

 ( 5α-reduced Steroid Metabolites ) 

Androstanedione, also known as 5α-androstanedione or as 5α-androstane-3,17-dione, is a natural product androstane (5α-androstane) steroid and an endogenous metabolite of like testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), and androstenedione. It is the C5 epimer of etiocholanedione (5β-androstanedione). Androstanedione is formed from androstenedione by 5α-reductase and from DHT by 17β-hydroxysteroid dehydrogenase.

In female genital skin, the conversion of androstenedione into DHT through 5α-androstanedione appears to be more important than the direct conversion of testosterone into DHT.

• Androstanedione (HMDB0000899) - Human Metabolome Database