Product Code Database
Androstadienol, or androsta-5,16-dien-3β-ol, is a 16-androstene class endogenous steroid, pheromone, and chemical intermediate to several other pheromones that is found in the sweat of both men and women. (2012). 9789400915671, Springer Science & Business Media. ISBN 9789400915671 (2012). 9788120345195, PHI Learning Pvt. Ltd.. ISBN 9788120345195
Androstadienol and androstadienone are odorless compounds secreted by the , and via conversion into the more powerfully-odorous androstenone and androstenol (catalyzed by Aerobic organism corynebacteria, particularly Corynebacterium xerosis, in men, and Micrococcaceae in women), are considered to be mainly responsible for the "musky" component of (underarm) body odor. (2025). 9780521841580, Cambridge University Press. ISBN 9780521841580 Androstadienol is biosynthesis from pregnenolone by the 16-ene-synthetase activity of CYP17A1, and is converted into androstadienone by 3β-hydroxysteroid dehydrogenase. Male sweat contains approximately five times as much androstenone as does female sweat, which can be explained by sex differences in androstadienol and androstadienone production.
Androstadienone, which is produced from androstadienol, has been found to affect brain activity. (2009). 9780521682169, Cambridge University Press. ISBN 9780521682169 Specifically, it has been found to activate the hypothalamus, most maximally the medial preoptic and anterior hypothalamic areas, in heterosexual women and homosexual men, but not in heterosexual men (who instead experienced hypothalamic activation in response to smelling estratetraenol, an estrogen-related pheromone, while heterosexual women and homosexual men did not). It has also been found to activate the anterior area of the inferior lateral prefrontal cortex, the superior temporal cortex, and olfactory system. The affected brain areas are thought to be involved in sexual behavior, attention, visual perception/recognition, and social cognition.
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