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Alternariol (commonly abbreviated as AOH) is a toxic metabolite of Alternaria fungi. It is an important contaminant in cereals and fruits. Alternariol exhibits fungicide and phytotoxic activity. It is reported to inhibit cholinesterase enzymes. Alternariol product page from Fermentek It is also a mycoestrogen.
A 2017 in vitro assay study reported alternariol to be a full agonist androgen agonist.
The acute toxicity of AOH and AME is low, but in vitro the substances show a strong and teratogenic effect. The substances are associated with the development of esophageal cancer.
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