Alprenolol

 ( 5-ht1a Antagonists ) 

Alprenolol, or alfeprol, alpheprol, and alprenololum ( Gubernal, Regletin, Yobir, Apllobal, Aptine, Aptol Duriles), is a non-selective beta blocker as well as a 5-HT_1A and 5-HT_1B receptor antagonist, used in the treatment of angina pectoris. It is no longer marketed by AstraZeneca, but may still be available from other pharmaceutical companies or generic drug.

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Pharmacology

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Pharmacokinetics The brain-to-blood ratio of alprenolol in humans has been found to be 16:1. For comparison, the brain-to-blood ratio of the highly lipophilic propranolol was 15:1 to 26:1 and of the hydrophilic atenolol was 0.2:1.

Categories: 5-ht1a Antagonists, 5-ht1b Antagonists, Allyl Compounds, Beta Blockers, Drugs Developed By Astrazeneca, N-isopropyl-phenoxypropanolamines

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