Alizapride

 ( Antiemetics ) 

Alizapride ( Litican, Plitican, Superan, Vergentan) is a dopamine antagonist with prokinetic and antiemetic effects used in the treatment of nausea and vomiting, including postoperative nausea and vomiting. It is structurally related to metoclopramide and other .

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Mechanism Alizapride acts on the vomiting center by blocking D2 dopamine receptors.

Since alizapride is able to cross the blood-brain barrier, adverse effects may include temporary extrapyramidal motor disorders such as acute dystonia and dyskinesia.

It has a plasma half-life of 3 hours.

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Synthesis The synthesis of Alizapride happens in multiple steps:

(2025). 9783131795250, Georg Thieme Verlag. ISBN 9783131795250

4-Aminosalicylic acid is first Methylation using dimethyl sulfate. A nitro group is then introduced that is reduced using Raney nickel to afford an amino group. The two amino groups are then closed to a triazole ring using sodium nitrite and hydrochloric acid. This is then condensed with 1-allyl-2-aminomethylpyrrolidine to afford Alizapride.

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